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Proposed criteria for severity of IOL in MDS


Proposed criteria for severity of iron overload in MDS
Ferritin ng/mL TSAT or LPI Cardiac Imaging msec Hepatic Imaging LIC (g/mg DW)
Negligible IOL ≤500 Normal >20 <3
Mild 501-1000 <50% or UN >20 <5
Moderate 1000-2500 50-80% or UN >20 5-7
Severe >2500 >80% or DET <20* >7**

*OR cardiac dysfunction: LVEF <50%

**OR hepatic dysfunction: AST/ALT >2xULN, fibrosis, cirrhosis

DET, detectable; DW, dry weight; IOL, iron overload; LIC, liver iron concentration; LPI, labile plasma iron; TSAT, transferrin saturation; ULN, upper limit of normal; UN, undetectable

Modified from Suzuki et al, Int J Hematol 2008: 88:30-35