Infections

• An iron rich environment enhances the growth of microorganisms. IOL leads to functional impairment of neutrophils, macrophages & natural killer cells^1-7.
• In SCT for hematologic malignancies, IOL (elevated pre-SCT SF, hepcidin level, or LIC) is a risk factor for significant infections⁸.
• An analysis from the US Medicare Registry indicated that TD MDS had a higher rate of infections than TI (81 vs 55.7%, p<0.001)⁹.
• In 138 RBC TD lower IPSS risk MDS, median time to first infection (TTI) in patients not receiving ICT was shorter (7.8 vs 27 months for ICT patients, p<0.0001)¹⁰.