Baseline

• Prior to initiation of ICT, the following baseline investigations should be completed (evidence level III, recommendation grade B):
  • Ophthalmological examination (slit lamp, retinal & corneal assessments; these should not delay the start of ICT in patients with significant IOL)
  • Audiometry
  • Complete blood count and differential (CBCD), creatinine
• Routine follow-up of patients receiving ICT should reflect Health Canada recommendations & include (evidence level III, recommendation grade B): info
  • Clinic visit monthly for 3 months, then quarterly
  • Ferritin, TSH/T3/T4, liver function tests, creatinine, glucose every 3 months (CBC & creatinine weekly for at least four weeks after initiation of DFX & after any dose increase)
  • Urinalysis (for proteinuria) monthly for DFX
  • Annual audiometry & ophthalmological assessments, more often for patients with abnormal values to ensure stability
  • 2-dimensional echocardiogram, if abnormal at baseline, if documented cardiac IOL, or if otherwise clinically indicated