Iron Overload in SCT: Congenital Anemias

• IOL is an established risk factor for inferior outcome in thalassemia patients undergoing SCT
• 3 classes of risk for morbidity were described, including:
  • hepatomegaly >2cm
  • the presence of portal fibrosis
  • OR irregular ICT history¹
• Patients with IOL not undergoing IOL reduction showed normalization of SF & LIC by 5 years post-SCT only in the lowest risk²
• Phlebotomy info post-SCT reduced IOL & improved organ function^3,4