Documented IOL

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• SF >1000ng/mL, consistently elevated over time to ensure IOL
  (≥2-3 measurements ≥1 month apart in the absence of infection/inflammation)
• Preferably with a fasting tsat >50% to exclude occult blood loss or with evidence of organ damage from IOL
  • With imaging documentation of organ iron overload if available
• Newer measures of biologically active iron such as enhanced labile plasma iron (eLPI) may be relevant in future
• Transfusion burden should be strictly documented
• Criteria for the severity of IOL have been proposed¹