| Studies examining iron overload, overall and leukemia-free survival in transfusion dependent lower IPSS risk MDS patients. | |||||
|---|---|---|---|---|---|
| Study | N | IOL measure | Endpoint | Findings | Reference |
| Malcovati 2006 | 467 | Per +1 RBCU/4wk |
OS, LFS OS |
HR 1.36, 1.40, p<0.0001 HR 1.42, p<0.001 |
[1] |
| De Swart 2012 | 1000 | Per +500SF >1000ng/mL |
Mortality rate Without DP With DP |
TI, 5%; TD, 24% TI, 32%; TD, 66% |
[2] |
| Hiwase 2017 | 408 | TD | OS | TD at any point is associated with inferior OS independent of the IPSS-R (p<0.0001) | [3] |
| CHF, congestive heart failure; DP, disease progression; GTT, glucose tolerance test; HR, hazard ratio; IOL, iron overload; IPSS-R, International Prognostic Scoring System-Revised; LFS, leukemia free survival; LFT, liver function tests (transaminases); n, number; OS, overall survival; p, probability; RBCU, red blood cell units; SF, serum ferritin; TD, transfusion dependent; TI, transfusion independent. Modified from Wells RA, et al. Leuk Res 2008 Sep;32(9):1338-53 and Leitch. HA, et al. Leuk Res. 2018 Nov;74:21-41. with permission. | |||||