| Table. Suggested monitoring of iron status | |
|---|---|
| Observation | Frequency |
| Iron intake rate | Each transfusion |
| Sequential serum ferritin, transferrin saturationa | >3-6 monthlyb |
| Organ functionc | As clinically indicated |
| Imaging assessment of organ irond | As clinically indicated |
|
atransferrin saturation >80% may indicate the presence of NTBI and >90% of LPI, measures of oxidative stress1,2. bfrequency determined by transfusion rate and iron burden. cHepatic, cardiac, endocrine. Measures may include BMD, ecg, electrocardiogram; echo, GTT, in addition to LFT. Up to 25% of hepatic IOL is underestimated by serum ferritin level3. dT2* MRI, R2 MRI or SQUID where available. References: 1Sahlstedt L, et al. Br J Haematol. 2001;113:836-838. 2Hoeks M, et al. Haematologica. 2019;pii:haematol.2018.212332. 3Nolte F, et. al. Ann Hematol. 2013;92:191-198. |
|