LPI in Lower-Risk MDS

EUMDS Registry, n=247

  • Impact of LPI on survival stratified by transfusion status as a time dependent variable (censored at time of starting chelation)
Chart - LPI in Lower-Risk MDS
  • Compared to those with undetectable LPI & TI, OS was significantly decreased in all groups, including TI with detectable LPI, after adjustment for: age at diagnosis, baseline IPSS-R, & ESA treatment (p≤0.02).
  • The adjusted HR for death with detectable LPI & TD was 6.50 (95% CI 2.39-17.0).
  • Conclusion: This study identifies LPI as a clinically relevant assay for detection of the toxic fraction of iron and its negative impact on HRQoL & OS in lower-risk MDS patients.