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ALLIVE: NRM, overall survival


NRM by pre-SCT eLPI

Chart - Cumulative incidence of NRM

OS by pre-SCT eLPI

Chart - Cumulative incidence of NRM
  • In MVA, elevated pre-SCT eLPI was an independent predictor of NRM (P=0.0082) and OS (P<0.0001)
  • The ALLIVE findings identify eLPI as a biomarker of IOL that appears to be clinically relevant & indicate a need for intervention
  • eLPI should be included in future studies of IOL reduction in SCT & non-SCT patients

ALLIVE, ALLogeneic Iron inVEstigators trial; eLPI, enhanced labile plasma iron; IOL, iron overload; MVA, multivariate analysis; NRM, non-relapse mortality; OS, overall survival; SCT, (hematopoietic) stem cell transplant.


Wermke M, et al. Lancet Haematol 2018;5:e201–e210.